I5659

Idebenone

≥98% (HPLC), powder

• Synonym(s): 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
• Empirical Formula (Hill Notation): C₁₉H₃₀O₅
• CAS Number: 58186-27-9
• Molecular Weight: 338.44
• MDL number: MFCD00274552
• UNSPSC Code: 12352204
• PubChem Substance ID: 329815386
• NACRES: NA.25

Properties

• product name: Idebenone, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• solubility: methanol: 50 mg/mL, clear to slightly hazy
• storage temp.: room temp
• SMILES string: O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
• InChI: 1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
• InChI key: JGPMMRGNQUBGND-UHFFFAOYSA-N

Description

General description

Idebenone is a short-chain benzoquinone drug.

Application

Idebenone has been used:

• to treat mutant myocilin (mMYOC) cells for drug treatment assay
• to validate C2C12 secondary cell screening assay
• to treat obese mice, to test whether idebenone and CoQ10 bind directly to peroxisome proliferator-activated receptor (PPAR)LBDs, His-tagged PPARα, δ and γ LBDs

Biochem/physiol Actions

Idebenone is used in the treatment of visual impairment in adolescents and adults with Leber′s hereditary optic neuropathy (LHON). It serves as an antioxidant. It helps to guard the heart muscle against oxidative stress.

A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable