I5532
Anti-Interleukin-21 Receptor, N-Terminal antibody produced in rabbit
~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IL-21R
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About This Item
MDL number:
UNSPSC Code:
51111800
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biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~60 kDa
species reactivity
human
concentration
~0.5 mg/mL
technique(s)
western blot: 0.5-1 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... IL21R(50615)
Immunogen
synthetic peptide corresponding to amino acids 20-32 of human IL-21 receptor precursor.
Biochem/physiol Actions
Interleukin-21 (IL-21) is a cytokine that regulates both innate and adaptive immunity. The biological effects of IL-21 are mediated by a heterodimeric receptor made up of IL-21R and a γ chain subunit. IL-21R is expressed in liver, thymus, dendritic cells , lymph nodes and spleen. Binding of IL-21 to the receptor leads to activation of JAK (JAK1 and JAK3), STAT (STAT1, 3, 4 and 5) proteins. IL-21R is important for sustained T cell responses during chronic viral infections, production of interferons against pathogens and protection against tumor formation.
Features and Benefits
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Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Giovanni Monteleone et al.
Discovery medicine, 8(42), 113-117 (2009-10-17)
Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin
Massimiliano Sarra et al.
Journal of biomedicine & biotechnology, 2010, 294582-294582 (2010-07-24)
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however evidence that B and
John S Yi et al.
Microbes and infection, 12(14-15), 1111-1119 (2010-09-08)
Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical
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