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I0144

Sigma-Aldrich

Indolicidin

≥97% (HPLC)

Synonym(s):

Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2

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About This Item

Empirical Formula (Hill Notation):
C100H132N26O13
CAS Number:
140896-21-5
Molecular Weight:
1906.28
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N6CCC[C@H]6C(=O)N[C@@H](Cc7c[nH]c8ccccc78)C(=O)N[C@@H](Cc9c[nH]c%10ccccc9%10)C(=O)N%11CCC[C@H]%11C(=O)N[C@@H](Cc%12c[nH]c%13ccccc%12%13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

General description

Chemical structure: peptide

Biochem/physiol Actions

Exhibits potent antimicrobial activity in vitro against bacteria and fungi.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
100M1483
050M1430
127K1383
126K1324
124K1116

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J Kovacs-Nolan et al.
The Journal of general virology, 90(Pt 8), 1892-1905 (2009-04-24)
Respiratory syncytial virus (RSV) is the leading cause of serious respiratory tract disease in children and calves; however, RSV vaccine development has been slow due to early observations that formalin-inactivated vaccines induced Th2-type immune responses and led to disease enhancement
Tatyana I Rokitskaya et al.
Biochimica et biophysica acta, 1808(1), 91-97 (2010-09-21)
Indolicidin, a 13-residue cationic peptide with extremely high tryptophan content, exhibits broad-spectrum antimicrobial as well as hemolytic activity. To gain insight into the mechanism of indolicidin action on membrane permeability, liposome leakage induced by this peptide was studied by using
J Kovacs-Nolan et al.
Vaccine, 27(14), 2055-2064 (2009-05-12)
The need to enhance the immunogenicity of purified subunit antigens and modulate resulting immune responses has prompted the development of new adjuvants. Here, the ability of CpG oligodeoxynucleotides (ODN), a bovine host defence peptide indolicidin, and polyphosphazene to synergistically combine
Setsuko Ando et al.
Journal of peptide science : an official publication of the European Peptide Society, 16(4), 171-177 (2010-03-03)
A series of Trp and Arg analogs of antibacterial indolicidin (Ind) was synthesized and the antimicrobial and hemolytic activities were investigated. [L(9)]Ind, [L(11)]Ind, [K(8),L(9)]Ind and [K(6, 8),L(9)]Ind showed desirable characteristics, exhibiting negligible hemolytic activity while keeping strong antibacterial activity. The
Linda Tomasinsig et al.
Infection and immunity, 78(4), 1781-1788 (2010-01-27)
Cathelicidins are peptide components of the innate immune system of mammals. Apart from exerting a direct antibiotic activity, they can also trigger specific defense responses in the host. Their roles in various pathophysiological conditions have been studied, but there is
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