GS66
GST M2-2, Recombinant Human
Synonym(s):
GST4, GSTM, GTHMUS, glutathione S-transferase mu 2
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.26
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
>95% (SDS-PAGE)
form
frozen liquid
specific activity
93.3 units/mg protein
mol wt
26 kDa
concentration
2.55 mg/mL
storage temp.
−70°C
Gene Information
human ... GSTM2(2946)
General description
using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.
Biochem/physiol Actions
Glutathione S-transferase mu 2 (GSTM2) is an enzyme that in humans is encoded by the GSTM2 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual′s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
Storage and Stability
The enzyme should be used by the end-user customer within 1 year of receipt.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The international journal of biochemistry & cell biology, 40(8), 1616-1628 (2008-03-01)
We show that a glutathione transferase (GST) protein, which is recognised by an antibody against the muscle-specific human GSTM2-2 (hGSTM2-2), is associated with the lumen of the sarcoplasmic reticulum (SR) of cardiac muscle, but not skeletal muscle. We further show
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