C207
4′-Chloro-3α-(diphenylmethoxy)tropane hydrochloride
solid
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C21H24ClNO · HCl
CAS Number:
Molecular Weight:
378.34
MDL number:
UNSPSC Code:
12352200
form
solid
color
white
solubility
H2O: 6.3 mg/mL
ethanol: 9.7 mg/mL
storage temp.
−20°C
SMILES string
Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccc(Cl)cc4
Gene Information
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
Biochem/physiol Actions
Dopamine transporter inhibitor that is less efficacious as a locomotor stimulant than cocaine; not recognized as being cocaine-like in a drug discrimination model in rats.
Caution
Photosensitive
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.
If you need assistance, please contact Customer Support.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
R H Kline et al.
Journal of medicinal chemistry, 40(6), 851-857 (1997-03-14)
A series of 2'- and 3'-substituted and 3',3"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs were designed and synthesized as novel probes for the dopamine transporter. All the analogs were evaluated for displacement of [3H]WIN 35,428 binding at the dopamine transporter and for inhibition
Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.
A H Newman et al.
Journal of medicinal chemistry, 37(15), 2258-2261 (1994-07-22)
J L Katz et al.
The Journal of pharmacology and experimental therapeutics, 288(1), 302-315 (1998-12-23)
The pharmacological effects were assessed for a series of 3alpha-diphenylmethoxy-1alphaH,5alphaH-tropane analogs which have structural similarities to cocaine. Like cocaine, these compounds displaced [3H]WIN 35,428 binding from rat caudate and had affinities ranging from approximately 10-fold greater than cocaine (Ki=11.8 nM)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
