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Key Documents

A4056

Sigma-Aldrich

Amrinone

Synonym(s):

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

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About This Item

Empirical Formula (Hill Notation):
C10H9N3O
CAS Number:
Molecular Weight:
187.20
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
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Assay

≥98% (TLC)

Quality Level

form

powder

solubility

1 M NaOH: 100 mg/mL

storage temp.

2-8°C

SMILES string

NC1=CC(=CNC1=O)c2ccncc2

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

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Biochem/physiol Actions

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1] Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney,[2] liver,[3] and heart.[4]
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1]

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Nuria Albet-Torres et al.
The Journal of biological chemistry, 284(34), 22926-22937 (2009-06-13)
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these
Kiyokazu Yunomae et al.
Journal of applied toxicology : JAT, 27(1), 78-85 (2006-12-06)
It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether-a-go-go related gene (hERG) activities by PKA-dependent pathway mediated phosphorylation through their
Greene Shepherd
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 63(19), 1828-1835 (2006-09-23)
The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed. Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. In overdose, beta-blockers
Alousi, A.A., et al.
Federation Proceedings, 37, 3692-3692 (1978)
Thiranat Tanwiphongtrakun et al.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 44(3), 183-185 (2006-10-14)
We came across a case who because of sustained hypotension with normal cardiac output was given amrinone which offered an initial excellent response but showed impotency later and its replacement by milrinone dramatically improved the hemodynamic status. The ensuing hypotension

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