A0976
Monoclonal Anti-Angiostatin antibody produced in mouse
clone 79735, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-Angiostatin Kringle 1-3
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
mouse
recombinant
expressed in E. coli
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
79735, monoclonal
form
lyophilized powder
mol wt
antigen 38 kDa
species reactivity
human
should not react with
mouse
technique(s)
western blot: 1-2 μg/mL
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PLG(5340)
General description
Angiostatin is an internal proteolytic fragment of plasminogen that has at least three kringle domains. This protein fragment functions as an endogenous angiogenesis inhibitor, and can also block endothelial cell proliferation,. Furthermore, angiostatin can specifically inhibit the growth of metastatic tumor.
Monoclonal Anti-Angiostatin recognizes human angiostatin. This antibody also recognizes plasminogen but shows no cross-reactivity with recombinant mouse angiostatin.
Monoclonal Anti-Angiostatin recognizes human angiostatin. This antibody also recognizes plasminogen but shows no cross-reactivity with recombinant mouse angiostatin.
Immunogen
recombinant human angiostatin kringle 1-3 expressed in E. coli.
Application
Mouse monoclonal anti-angiostatin antibody can be used for western blot applications at 1-2 μg/mL.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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José Ángel Nicolás-Ávila et al.
STAR protocols, 2(1), 100286-100286 (2021-01-26)
Cardiac exophers are membrane-bound extracellular vesicles released by cardiomyocytes with varied content and an average diameter of 3.5 μm. Here, we provide a detailed protocol to enable the identification and purification of cardiomyocyte-derived exophers by using fluorescence-activated cell sorting for downstream
Z Wu et al.
Biochemical and biophysical research communications, 236(3), 651-654 (1997-07-30)
Angiostatin, a 38 kDa internal fragment of plasminogen, is an antiangiogenic endothelial cell inhibitor. It regresses several primary and metastatic tumors in mice. To produce recombinant angiostatin for further structural and functional studies, the mouse angiostatin gene preceded by a
M S O'Reilly et al.
Cell, 79(2), 315-328 (1994-10-21)
The phenomenon of inhibition of tumor growth by tumor mass has been repeatedly studied, but without elucidation of a satisfactory mechanism. In our animal model, a primary tumor inhibits its remote metastases. After tumor removal, metastases neovascularize and grow. When
Y Cao et al.
The Journal of biological chemistry, 271(46), 29461-29467 (1996-11-15)
Recently we have identified angiostatin, an endogenous angiogenesis inhibitor of 38 kDa which specifically blocks the growth of endothelial cells (O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C. , Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y.
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