59815
1-(4-Isothiocyanatobenzyl)ethylenediamine-N,N,N′,N′-tetraacetic acid
~90% (HPLC)
Synonym(s):
Isothiocyanatobenzyl-EDTA
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10 MG
$1,170.00
About This Item
Empirical Formula (Hill Notation):
C18H21N3O8S
CAS Number:
Molecular Weight:
439.44
Beilstein:
8363400
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25
Recommended Products
Assay
~90% (HPLC)
Quality Level
shipped in
wet ice
storage temp.
−20°C
SMILES string
OC(=O)CN(CC(Cc1ccc(cc1)N=C=S)N(CC(O)=O)CC(O)=O)CC(O)=O
InChI
1S/C18H21N3O8S/c22-15(23)7-20(8-16(24)25)6-14(21(9-17(26)27)10-18(28)29)5-12-1-3-13(4-2-12)19-11-30/h1-4,14H,5-10H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)
InChI key
VHMWJVAFPCGUTJ-UHFFFAOYSA-N
Application
Isothiocyanatobenzyl-EDTA is a bifunctional chelator used in bioconjugation chemistry to label primary amine containing molecules and proteins preferentially at their N-terminals.
Other Notes
Amine-reactive probe, useful for antibody chelate labeling[1]
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S V Deshpande et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31(2), 218-224 (1990-02-01)
The metabolism of radiolabeled antibodies is important for radioimmunoimaging and therapy. The loss of indium-111 (111In) from the chelate can pose problems in imaging and increases the radiation dose to normal tissues. We have evaluated the loss in vivo of
K Shah et al.
Bioconjugate chemistry, 7(3), 283-289 (1996-05-01)
The synthesis of a C-5 modified uridine phosphoramidite which contains a primary amino group protected with Fmoc is described. During cleavage and deprotection of chemically synthesized RNA, the Fmoc protecting group is removed to yield a free amino group at
Z Yao et al.
Nuclear medicine and biology, 22(2), 199-203 (1995-02-01)
Tn antigen is a glycosylated tumor associated antigen and a murine monoclonal antibody, MLS128, has been identified to react with it. The potential of MLS128 for the radioimmunoimaging of colorectal cancer was studied. MLS128 was labeled with radioiodine by the
T M Rana et al.
Bioconjugate chemistry, 1(5), 357-362 (1990-09-01)
Conjugates of monoclonal antibodies with drugs, toxins, radionuclides, and other agents are in widespread use in therapeutic trials and as clinical research tools. The characterization of these immunoconjugates generally does not include determining the individual sites at which such agents
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