N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.
N, N-Diisopropylethylamine is a hindered non-nucleophilic amine base used in alkylation, aldol-like reactions, eliminations, and selective generation of enolates. It is widely used as a proton scavenger in organic synthesis. Due to its less nucleophilic nature, it produces less byproducts.
Application
N, N-Diisopropylethylamine can be used as a base:
In the palladium (0)-catalyzed alkoxy carbonylation of allyl phosphates and acetate.
In the selective enolate formation along with boryl triflates.
In the C–N coupling of aryl halides with nitroarenes in the presence of nickel catalyst.
N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.[1]
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Angiogenin (ANG), an endogenous protein that plays a key role in cell growth and survival, has been scrutinised here as promising nanomedicine tool for the modulation of pro-/anti-angiogenic processes in brain cancer therapy. Specifically, peptide fragments from the putative cell
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