CH2900018

Calcium Levofolinate Hydrate / Levoleucovorin Calcium Pentahydrate

Ph. Eur.

• Synonym(s): L-Calcium Folinate, L-Leucovorin Calcium, Levofolinate Calcium Hydrate, Levoleucovorin Calcium
• UNSPSC Code: 41116107

Properties

• biological source: synthetic
• Quality Level: 600
• grade: GMO free; GMP; Halal; Kosher
• Agency: Ph. Eur.; USP
• form: powder
• application(s): liquid formulation; pharmaceutical; solid formulation
• storage temp.: 2-8°C

Description

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Calcium Levofolinate Hydrate has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

Packaging

Customized packaging possible

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable