Myocardial zonula adherens protein, also known as GRINL1A upstream protein (Gup), and encoded by the gene name MYZAP or MYOZAP, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase–RhoA interacting protein (MRIP) and acts as an activator of Rhodependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, Nmethyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.
Immunogen
Epitope: C-terminus
KLH-conjugated synthetic peptide corresponding to the C-terminus of human MYOZAP.
Application
Anti-MYOZAP Antibody detects level of MYOZAP & has been published & validated for use in MYOZAP.
Research Category Cell Structure
Research Sub Category Cytoskeleton
Quality
Evaluated by Western Blotting in rat kidney tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected MYOZAP in rat kidney tissue lysate.
Target description
~54 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 11 isoforms produced by alternative splicing ranging between ~44 kDa and ~54 kDa
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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