A cell-permeable, reversible, and ATP-competitive cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC50 = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.
A cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC50 = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.
Biochem/physiol Actions
Cell permeable: yes
Primary Target (LPS)-stimulated IL-1 and TNF-α production
Product competes with ATP.
Reversible: yes
Target IC50: 1 µM inhibiting lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production
Warning
Toxicity: Irritant (B)
Other Notes
Frasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389. Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63. Lee, J.C., et al. 1995. Nature 372, 739. Prichett, W., et al. 1995. J. Inflamm. 45, 97. Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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