526520

PIM1 Inhibitor II

• Synonym(s): PIM1 Inhibitor II, 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine
• Empirical Formula (Hill Notation): C₁₈H₁₁BrN₂O₂
• CAS Number: 491871-58-0
• Molecular Weight: 367.20
• UNSPSC Code: 12352200

Properties

• Assay: ≥90% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

This product has been discontinued.

A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC₅₀ = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC₅₀ >20 µM).

A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC₅₀ = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC₅₀ >20 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
PIM1

Product competes with ATP.

Reversible: no

Target IC₅₀: 50 nM against PIM1 kinase

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett.17, 1679.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10-13 - German Storage Class 10 to 13