This is soluble in the following solvents as follows:
DMSO: 100 mg/mL (162.11 mM)
Ethanol: 100 mg/mL (162.11 mM)
Water: Insoluble
19-144
Phorbol 12-Myristate 13-Acetate
≥99% (HPLC), solid, PKC activator, Upstate®
Synonym(s):
12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA
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1 MG
$207.00
About This Item
UNSPSC Code:
12352211
eCl@ss:
32160405
NACRES:
NA.41
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Product Name
Phorbol 12-Myristate 13-Acetate,
form
solid
Quality Level
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
shipped in
wet ice
General description
Phorbol 12-Myristate 13-Acetate (PMA) is obtained from the unripe fruit of Sapium indicum. It is a pro-inflammatory agent. PMA shows its effects by the release of cytokines, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and proteases that result in tissue damage or activates histamine production. This promotes vascular remodeling, heat, and redness.[1] PMA exhibits antimicrobial, proliferative, antiproliferative, anti-neoplastic effects.[2]
Application
Biochem/physiol Actions
Phorbol 12-Myristate 13-Acetate is a tumor-promoting phorbol ester. It regulates various processes such as gene transcription, cellular growth and differentiation, apoptosis, the immune response, and receptor desensitization via activating protein kinase C (PKC) signaling pathways.[6] It promotes differentiation of human monocytic THP-1 cells to functional macrophages.[5]
Physical form
C36H56O8
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Certificates of Analysis (COA)
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Phorbol-12-myristate-13-acetate (PMA) and 1,25-dihydroxyvitamin D3 (VD3) are stimuli commonly used to induce macrophage differentiation in monocytic cell lines, but the extent of differentiation in comparison to primary tissue macrophages is unclear. Here, we examine the morphological/phenotypic markers associated with differentiation
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