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Sigma-Aldrich

Anti-MAPKAP-K2 Antibody, clone 7H4.2

clone 7H4.2, Upstate®, from mouse

Synonym(s):

MAPK-activated protein kinase 2, MAPKAP kinase 2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

7H4.2, monoclonal

species reactivity

human, rat, mouse

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_004759.3
NM_032960.2

UniProt accession no.

P49137

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MAPKAPK2(9261)

Immunogen

KLH-conjugated synthetic peptide of the C-terminus of the long form of human MAPKAP-K2.

Application

Suggested dilutions:
Immunoblot Analysis: 1:500
Immunoprecipitation: 1:20
Anti-MAPKAP-K2 Antibody, clone 7H4.2 detects level of MAPKAP-K2 & has been published & validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
MAP Kinases

Kinases & Phosphatases

Quality

Routinely evaluated by immunoblot.

Target description

45 kDa

Physical form

200 µg (1 mg/mL) of mouse monoclonal IgG in PBS containing 0.1% sodium azide.
Format: Purified
Protein A purified

Storage and Stability

2 years at -20°C from date of shipment.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Isaac A Manke et al.
Molecular cell, 17(1), 37-48 (2005-01-05)
The cellular response to DNA damage is mediated by evolutionarily conserved Ser/Thr kinases, phosphorylation of Cdc25 protein phosphatases, binding to 14-3-3 proteins, and exit from the cell cycle. To investigate DNA damage responses mediated by the p38/stress-activated protein kinase (SAPK)
Ainsley A Culbert et al.
The Journal of biological chemistry, 281(33), 23658-23667 (2006-06-16)
MAPK-activated protein kinase 2 (MAPKAP K2 or MK2) is one of several kinases directly regulated by p38 MAPK. A role for p38 MAPK in the pathology of Alzheimer disease (AD) has previously been suggested. Here, we provide evidence to suggest
Matthieu Lemaire et al.
Cell cycle (Georgetown, Tex.), 5(15), 1649-1653 (2006-07-25)
CDC25B is one of the three human phosphatases that are involved in the control of the activation of cyclin-dependent kinases. CDC25B participates in regulating entry into mitosis and appears to play a key role in the checkpoint response to DNA
L Xu et al.
Oncogene, 25(21), 2987-2998 (2006-01-13)
Although cell invasion is a necessary early step in cancer metastasis, its regulation is not well understood. We have previously shown, in human prostate cancer, that transforming growth factor beta (TGFbeta)-mediated increases in cell invasion are dependent upon activation of

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