640014P
Avanti
Ceramide Synthase (CerS5/CerS6) Assay Kit
Avanti Research™ - A Croda Brand
Synonym(s):
Ceramide Synthase (CerS5/CerS6) Assay Kit, CerS5/S6 Assay Kit
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About This Item
UNSPSC Code:
12161503
Recommended Products
form
powder
usage
sufficient for ~275 reactions
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
The CerS Assay Kit provides an easy to use assay for measuring CerS activity in biological samples. This Kit offers the advantage of a short assay time requiring only small amounts of biological material while eliminating TLC as a separation technique with its attendant degradation of NBD sphinganine.
Biochem/physiol Actions
Ceramide synthase (cerS) catalyzes the acylation of sphinganine (dihydrosphingosine) to yield dihydroceramide and sphingosine to yield ceramide. There are six cerS (cerS1-6), which differ in their specificity to yield ceramides of different chain length. Ceramide is a key intermediate in sphingolipid metabolism and an key signaling molecule.
Packaging
Kit contains:
0.3mg 16:0 fatty acyl-CoA
0.1mg NBD Sphinganine
0.3mg 16:0 fatty acyl-CoA
0.1mg NBD Sphinganine
Storage and Stability
Note: this product should be stored at -20° for up to 6 months.
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
Hartmann D, et al.
The International Journal of Biochemistry & Cell Biology, 45(7), 1195-1203 (2013)
Mammalian Ceramide Synthases
Michal L, et al.
IUBMB Life, 62(5), 347?356-347?356 (2010)
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis.
Pewzner-Jung Y, et al.
The Journal of Biological Chemistry, 281(35), 25001-25005 (2006)
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