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638013

Sigma-Aldrich

4-Diphenylphosphanylbenzoic acid, 2-(trimethylsilyl)ethyl ester solution

0.5 M in THF

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About This Item

Empirical Formula (Hill Notation):
C24H27O2PSi
CAS Number:
566190-45-2
Molecular Weight:
406.53
MDL number:
MFCD07369722
UNSPSC Code:
12352108
PubChem Substance ID:
24882904

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

concentration

0.5 M in THF

density

0.925 g/mL at 25 °C

functional group

phosphine

SMILES string

C[Si](C)(C)CCOC(=O)c1ccc(cc1)P(c2ccccc2)c3ccccc3

InChI

1S/C24H27O2PSi/c1-28(2,3)19-18-26-24(25)20-14-16-23(17-15-20)27(21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-17H,18-19H2,1-3H3

InChI key

QTYUNPJLGFKKRV-UHFFFAOYSA-N

Application

4-Diphenylphosphanyl-benzoic acid 2-trimethylsilanyl-ethyl ester (DPPBE) was developed as an efficient alternative to triphenylphosphine in the Mitsunobu reaction since the phosphine oxide formed during the reaction can be easily removed during workup.
Reagent for:
  • Synthesis of alkenes
  • Methylation of aldehydes
  • Mitsunobu reactions

Signal Word

Danger

Hazard Statements

H225,H319,H335,H351

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

-4.0 °F - closed cup

Flash Point(C)

-20 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
04719JE
16930LC

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Removable phosphine reagents for the Mitsunobu reaction.
Yoakim C, et al.
Synlett, 2003(04), 0473-0476 (2003)

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