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Sigma-Aldrich

4-Hydroxy-8-(trifluoromethyl)quinoline

98%

Synonym(s):

8-(Trifluoromethyl)-4-quinolinol

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About This Item

Empirical Formula (Hill Notation):
C10H6F3NO
CAS Number:
23779-96-6
Molecular Weight:
213.16
EC Number:
245-879-3
MDL number:
MFCD00134577
UNSPSC Code:
12352100
PubChem Substance ID:
24863884

Assay

98%

mp

174-176 °C (lit.)

SMILES string

Oc1ccnc2c(cccc12)C(F)(F)F

InChI

1S/C10H6F3NO/c11-10(12,13)7-3-1-2-6-8(15)4-5-14-9(6)7/h1-5H,(H,14,15)

InChI key

UDRWADJLLWWJOE-UHFFFAOYSA-N

General description

4-Hydroxy-8-(trifluoromethyl)quinolone (8-(Trifluoromethyl)-4-quinolinol) is a heterocyclic building block. Various 4-hydroxy-8-trifluoromethyl-quinoline derivatives have been prepared via multi step reactions and were tested for their antimicrobial actions.

Application

4-Hydroxy-8-(trifluoromethyl)quinolone (4-Hydroxy-8-trifluoromethylquinolone) may be used in the synthesis of analgesic compound, floctafenine.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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William Andrew Publishing
Pharmaceutical Manufacturing Encyclopedia, 4, 1621-1621 (2013)
K D Thomas et al.
European journal of medicinal chemistry, 46(11), 5283-5292 (2011-09-13)
Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were

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