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Key Documents

149233

Sigma-Aldrich

2,6-Dimethyl-2,5-heptadien-4-one

95%

Synonym(s):

Phorone, sym-Diisopropylideneacetone

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About This Item

Linear Formula:
(CH3)2C=CHCOCH=C(CH3)2
CAS Number:
Molecular Weight:
138.21
Beilstein:
1699751
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

vapor density

4.8 (vs air)

vapor pressure

0.38 mmHg ( 20 °C)
1 mmHg ( 42 °C)

Assay

95%

refractive index

n20/D 1.497 (lit.)

bp

198-199 °C (lit.)

mp

23-26 °C (lit.)

density

0.885 g/mL at 25 °C (lit.)

SMILES string

C\C(C)=C\C(=O)\C=C(\C)C

InChI

1S/C9H14O/c1-7(2)5-9(10)6-8(3)4/h5-6H,1-4H3

InChI key

MTZWHHIREPJPTG-UHFFFAOYSA-N

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

174.2 °F - closed cup

Flash Point(C)

79 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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F Bahrami et al.
Chemico-biological interactions, 128(2), 97-113 (2000-10-12)
Previously we reported that methylsulphonyl-2,6-dichlorobenzene, 2, 6-(diCl-MeSO(2)-B), was irreversibly bound to the olfactory mucosa of mice and induced necrosis of the Bowman's glands with subsequent neuroepithelial degeneration and detachment. In this study, autoradiography and histopathology were used to determine tissue-localization
Tom S Chan et al.
Free radical biology & medicine, 38(7), 867-873 (2005-03-08)
Most animals synthesize ascorbate. It is an essential enzymatic cofactor for the synthesis of a variety of biological molecules and also a powerful antioxidant. There is, however, little direct evidence supporting an antioxidant role for endogenously produced ascorbate. Recently, we
Sophie Cazanave et al.
Journal of hepatology, 46(5), 858-868 (2007-02-06)
The agonistic Jo2 anti-Fas antibody reproduces human fulminant hepatitis in mice. We tested the hypothesis that enhancing hepatic glutathione (GSH) stores may prevent Jo2-induced apoptosis. We fed mice with a normal diet or a sulfur amino acid-enriched (SAA(+)) diet increasing
Tom S Chan et al.
Biochemical and biophysical research communications, 317(1), 149-156 (2004-03-30)
Using isolated rat hepatocytes we have shown that glutathione (GSH) depletion by glutathione-S-transferase (GST)-catalyzed conjugation with 1-bromoheptane or phorone was accompanied by a significant elevation in ascorbate synthesis. Glycogenolysis was also stimulated without a significant rise in glucose synthesis. Furthermore
T Oguro et al.
The Journal of pharmacology and experimental therapeutics, 287(2), 773-778 (1998-11-10)
Phorone, a glutathione (GSH) depletor, induces the expression of mRNAs of heme oxygenase-1 (HO-1) and c-jun by mediating the activation of activated protein-1 (AP-1) in rat livers. We have shown that phorone activates c-Jun N-terminal kinase (JNK), thus leading to

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