149233
2,6-Dimethyl-2,5-heptadien-4-one
95%
Synonym(s):
Phorone, sym-Diisopropylideneacetone
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About This Item
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vapor density
4.8 (vs air)
vapor pressure
0.38 mmHg ( 20 °C)
1 mmHg ( 42 °C)
Assay
95%
refractive index
n20/D 1.497 (lit.)
bp
198-199 °C (lit.)
mp
23-26 °C (lit.)
density
0.885 g/mL at 25 °C (lit.)
SMILES string
C\C(C)=C\C(=O)\C=C(\C)C
InChI
1S/C9H14O/c1-7(2)5-9(10)6-8(3)4/h5-6H,1-4H3
InChI key
MTZWHHIREPJPTG-UHFFFAOYSA-N
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
174.2 °F - closed cup
Flash Point(C)
79 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Chemico-biological interactions, 128(2), 97-113 (2000-10-12)
Previously we reported that methylsulphonyl-2,6-dichlorobenzene, 2, 6-(diCl-MeSO(2)-B), was irreversibly bound to the olfactory mucosa of mice and induced necrosis of the Bowman's glands with subsequent neuroepithelial degeneration and detachment. In this study, autoradiography and histopathology were used to determine tissue-localization
Free radical biology & medicine, 38(7), 867-873 (2005-03-08)
Most animals synthesize ascorbate. It is an essential enzymatic cofactor for the synthesis of a variety of biological molecules and also a powerful antioxidant. There is, however, little direct evidence supporting an antioxidant role for endogenously produced ascorbate. Recently, we
Journal of hepatology, 46(5), 858-868 (2007-02-06)
The agonistic Jo2 anti-Fas antibody reproduces human fulminant hepatitis in mice. We tested the hypothesis that enhancing hepatic glutathione (GSH) stores may prevent Jo2-induced apoptosis. We fed mice with a normal diet or a sulfur amino acid-enriched (SAA(+)) diet increasing
Biochemical and biophysical research communications, 317(1), 149-156 (2004-03-30)
Using isolated rat hepatocytes we have shown that glutathione (GSH) depletion by glutathione-S-transferase (GST)-catalyzed conjugation with 1-bromoheptane or phorone was accompanied by a significant elevation in ascorbate synthesis. Glycogenolysis was also stimulated without a significant rise in glucose synthesis. Furthermore
The Journal of pharmacology and experimental therapeutics, 287(2), 773-778 (1998-11-10)
Phorone, a glutathione (GSH) depletor, induces the expression of mRNAs of heme oxygenase-1 (HO-1) and c-jun by mediating the activation of activated protein-1 (AP-1) in rat livers. We have shown that phorone activates c-Jun N-terminal kinase (JNK), thus leading to
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