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100072

Sigma-Aldrich

Isoxanthopterin

97%

Synonym(s):

2-Amino-4,7-dihydroxy-1,3,5,8-tetraazanaphthalene, 2-Amino-4,7-dihydroxypteridine, 2-Amino-4,7-pteridinediol

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About This Item

Empirical Formula (Hill Notation):
C6H5N5O2
CAS Number:
529-69-1
Molecular Weight:
179.14
Beilstein:
181594
EC Number:
208-469-5
MDL number:
MFCD00006696
UNSPSC Code:
12352103
PubChem Substance ID:
329748876

Assay

97%

SMILES string

NC1=NC2=C(N=CC(=O)N2)C(=O)N1

InChI

1S/C6H5N5O2/c7-6-10-4-3(5(13)11-6)8-1-2(12)9-4/h1H,(H4,7,9,10,11,12,13)

InChI key

GLKCOBIIZKYKFN-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
06155LF
04901PF
02611LX

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T Yamamoto et al.
Journal of chromatography. B, Biomedical applications, 681(2), 395-400 (1996-06-07)
An assay for human plasma xanthine oxidase activity was developed with pterin as the substrate and the separation of product (isoxanthopterin) by high-performance liquid chromatography with a fluorescence detector. The reaction mixture consists of 60 microliters of plasma and 240
I Ziegler
Journal of cellular biochemistry, 28(3), 197-206 (1985-01-01)
After iodine oxidation, biopterin, 6-hydroxymethylpterin, and 6-formylpterin were identified in mouse spleen lymphocytes by means of reverse-phase HPLC, Crithidia assay, and oxidative degradation. Concanavalin A activation induces a 30-fold increase in the pteridine amounts; biopterin as well as the sum
Gabriella Allegri et al.
Bioanalysis, 4(14), 1739-1746 (2012-08-11)
The present work describes an analytical method for urinary pterins by LC-MS/MS, with emphasis on the separation of 6- and 7-positional isomers of bio- and neopterins. Urine sample preparation consisted of oxidation by MnO(2), filtration and direct dilution in the
A Atlante et al.
Brain research. Brain research protocols, 6(1-2), 1-5 (2000-11-22)
Since xanthine oxidase (XO, Xanthine:oxidoreductase, E.C.1.2.3.22) is a key enzyme in reactive oxygen specie formation which plays a major role in cell oxidative stress, the availability of a sensitive and simple assay useful to detect its activity in monolayer cell
Yuichi Komaki et al.
Pulmonary pharmacology & therapeutics, 18(4), 297-302 (2005-03-22)
Reactive oxygen species have been reported to be involved in the airway inflammatory process of chronic obstructive pulmonary disease (COPD). The aim of this study was to quantify the activity of xanthine oxidase (XO), which generates a potent radical superoxide
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