Generation 2 to generation 5 poly(amidoamine) (PAMAM) dendrimers having different terminal functionalities were analyzed by capillary electrophoresis (CE). Polyacrylamide gel electrophoresis was also used to assess the composition of the individual generations for comparison with the CE results. Separation of
Journal of medicinal chemistry, 47(26), 6439-6442 (2004-12-14)
Bradykinin B1 receptor antagonists embody a potentially novel approach for the treatment of chronic pain and inflammation. A series of 2,3-diaminopyridine B1 antagonists was optimized to have sub-nanomolar affinity and good pharmacokinetic properties. Lead compounds were shown to exhibit good
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(8-9), 2181-2184 (2004-07-14)
The charge-transfer interaction of 2,3-diaminopyridine (DAPY) and iodine has been investigated spectrophotometrically in the solvents chloroform and dichloromethane at room temperature. The results indicate the formation of 1:2 charge-transfer complex in each solvent with the observation of the two characteristic
A novel class of 2,3-diaminopyridine bradykinin B1 receptor antagonists is disclosed. Structure-activity relationship studies (SARs) that led to compounds with significantly improved potency and pharmacokinetic properties relative to the lead compound are described.
Slices of hippocampus of the rat, preincubated with [3H]noradrenaline ([3H]NA), were used to investigated the effects of omega-conotoxin GVIA (omega-CTX) on the release of [3H]NA evoked by 3,4-diaminopyridine (3,4-DAP, 200 microM), veratridine (0.7 microM) or monensin (0.01 microM) in the
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