SML3759

MU1742

≥95% (HPLC)

• Synonym(s): 4-(1-((4-Fluoro-1-methylpiperidin-4-yl)methyl)-4-(5-fluoropyridin-2-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine, MU 1742, MU-1742
• Empirical Formula (Hill Notation): C₂₂H₂₂F₂N₆
• Molecular Weight: 408.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD35065201
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC5(CCN(CC5)C)C[n]1cnc(c1c3c4c([nH]cc4)ncc3)c2ncc(cc2)F
• InChI key: SWOIFXHMBKFCRM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

MU1742 is an orally active, potent and selective casein kinase 1 inhibitor (CK1α/δ/ε IC50 = 7/6/28 nM; p38α IC50 >3 μM) with high kinome-wide selectivity. MU1742 inhibits CLL19-induced chemotaxis (IC50 = 200 nM; MEC1 cells) and CK1δ/ε-dependent DVL3 phosphorylation (IC50 = 200 nM post 18h treatment; HL60 cells) in cultures and in lung tissue in mice in vivo (5h post 100 mg/kg p.o. using HCl salt form).

Orally active, potent and selective casein kinase 1 (CK1, CKI) inhibitor in vitro and in vivo.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable