Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM, 329 nM, 1.49 μM, respectively, against GSDMD clevage by human caspase-1, -5, -4 in cell-free enzymatic assays) that suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis.
Selective gasdermin D (GSDMD) clevage inhibitor that suppresses NLRP3 inflammasome activation and downstream pyroptosis.
The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
description
targeting mouse Gsdmd
form
(Powder or Lyophilized powder or film)
form
powder
form
powder, lyophilized solid
form
lyophilized powder
assay
≥95% (HPLC)
assay
≥95% (HPLC)
assay
≥98% (HPLC)
assay
-
Quality Level
100
Quality Level
100
Quality Level
100
Quality Level
100
storage temp.
-10 to -25°C
storage temp.
−20°C
storage temp.
−20°C
storage temp.
−20°C
storage condition
desiccated
storage condition
-
storage condition
OK to freeze, desiccated
storage condition
-
color
white to off-white
color
white to off-white
color
white to off-white
color
-
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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