SML3542
SGC-UBD253
≥98% (HPLC)
Synonym(s):
3-(8-Chloro-3-(2-(2-methoxybenzylamino)-2-oxoethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid
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About This Item
Empirical Formula (Hill Notation):
C21H20ClN3O5
Molecular Weight:
429.85
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
O=C(NCC(C=CC=C1)=C1OC)CN(C(CCC(O)=O)=N2)C(C3=C2C(Cl)=CC=C3)=O
Biochem/physiol Actions
Cell penetrant, potent and selective chemical probe for the ubiquitin binding domain (UBD) of HDAC6 (histone deacetylase 6)
SGC-UBD253 is a cell penetrant, potent and selective chemical probe for the ubiquitin binding domain (UBD) of HDAC6 (histone deacetylase 6). SGC-UBD253 potently binds to HDAC6 UBD (KD = 84 nM) and inhibits the HDAC6-ISG15 interaction (EC50 = 1.9 µM).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Renato Ferreira de Freitas et al.
Journal of medicinal chemistry, 61(10), 4517-4527 (2018-05-10)
HDAC6 plays a central role in the recruitment of protein aggregates for lysosomal degradation and is a promising target for combination therapy with proteasome inhibitors in multiple myeloma. Pharmacologically displacing ubiquitin from the zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 is
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