This is a research grade product. Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
SML3422
Pritelivir
≥98% (HPLC)
Synonym(s):
AIC316, BAY 57-1293, BAY57-1293, N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide
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About This Item
Empirical Formula (Hill Notation):
C18H18N4O3S2
CAS Number:
Molecular Weight:
402.49
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
eCl@ss:
32160701
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N)c1[s]c(nc1C)N(C)C(=O)Cc2ccc(cc2)c3ncccc3
InChI
1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)
InChI key
IVZKZONQVYTCKC-UHFFFAOYSA-N
Biochem/physiol Actions
Potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor with antiviral efficacy in cultures and in mice in vivo.
Pritelivir (AIC316; BAY57-1293) is a potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor (IC50 = 30 nM using wt HSV-1F ATPase complex UL5-UL52 & 1 mM ATP) with antiviral efficacy in Vero cultures (replication IC50 = 20 nM against HSV-2G, wt and Acyclovir-resistant HSV-1F; MOI = 0.0025) and in mice in vivo (ED50 = 0.5 mg/kg 3x daily p.o. using HSV-1 Walki or HSV-2 MS), being >28 times more potent than acyclovir and valacyclovir.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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