Skip to Content
Merck

Key Documents

View All Documentation

Skip To

SML3386

Macitentan

≥98% (HPLC)

Synonym(s):

ACT 064992, ACT-064992, ACT064992, Actelion-1, N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propyl-sulfamide

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C19H20Br2N6O4S
CAS Number:
441798-33-0
Molecular Weight:
588.27
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD17167076
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

BrC1=CC=C(C=C1)C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(NCCC)(=O)=O

InChI

1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)

InChI key

JGCMEBMXRHSZKX-UHFFFAOYSA-N

Biochem/physiol Actions

Macitentan (ACT-064992; actelion-1) is an orally active, potent endothelin (ET) receptor antagonist that blocks ET-1-induced cellular calicum response (IC50 in nM = 0.9/HPASMC, 0.8/RASMC, 1.84/m3T3), as well as ET-1-induced contractions of rat aortic rings (ETA) and S6c-induced rat tracheal rings (ETB) ex vivo (pA2 = 7.6 and 5.9, respectively). Macitentan displays therapeutic efficacy in rat hypertension models in vivo (0.3-100 mg/kg p.o. via single or daily dosing).
Orally active, potent endothelin (ET) receptor antagonist with therapeutic efficacy against hypertension in vivo.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
1A056601A0569027102
Macitentan ≥98% (HPLC)

Sigma-Aldrich

SML3386

Macitentan

USP

USP

1A05660

Macitentan Sulfamide Dimer

USP

USP

1A05690

Macitentan Amine

Citric acid monohydrate puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

Sigma-Aldrich

27102

Citric acid monohydrate

description

≥98% (HPLC)

description

Pharmaceutical Analytical Impurity (PAI)

description

Pharmaceutical Analytical Impurity (PAI)

description

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

assay

≥98% (HPLC)

assay

-

assay

-

assay

99.5-100.5% (based on anhydrous substance)

form

powder

form

solid

form

solid

form

grit

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Codes

H360FD

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters