SML3337
CBR-470-1, racemic
≥98% (HPLC)
Synonym(s):
(± )-3-((4-chlorophenyl)sulfonyl)-4-(isobutylamino)tetrahydrothiophene 1,1-dioxide, 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel- (ACI)
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About This Item
Empirical Formula (Hill Notation):
C14H20ClNO4S2
CAS Number:
Molecular Weight:
365.90
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2%, clear
storage temp.
2-8°C
Biochem/physiol Actions
CBR-470-1 is an Inhibitor of the glycolytic enzyme PGK1 that induces Nrf2 activity. PGK1 inhibition results in acculumation of methylglyoxalyl (MGO), a toxic, reactive metabolite removed by other enzymes. The accumulated MGO then irreversibly reacts with Keap1 forming inactive Keap1 dimers, resulting in accumulation of Nrf2.
Inhibitor of the glycolytic enzyme PGK1 inducing Nrf2 activity
1 of 1
This Item | |
|---|---|
| description ≥98% (HPLC) | description roll, white glass, W × L 1.5 in. (38.1 mm) × 450 ft (137.2 m), pkg of 1 ea |
| assay ≥98% (HPLC) | assay - |
| form powder | form - |
| Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 2%, clear | solubility - |
| color white to beige | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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