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SML2845

Betrixaban

≥98% (HPLC)

Synonym(s):

PRT054021, MK-4448, MLN1021, N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide, N-(5-Chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, PRT-054021

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5 mg
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€ 89,30
€ 75,90
25 mg
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€ 363,00
€ 308,55

About This Item

Empirical Formula (Hill Notation):
C23H22ClN5O3
CAS Number:
330942-05-7
Molecular Weight:
451.91
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD16038040
Assay:
≥98% (HPLC)
Form:
powder

€ 75,90

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CN=C(C=C1)NC(C2=C(NC(C3=CC=C(C(N(C)C)=N)C=C3)=O)C=CC(OC)=C2)=O

InChI

1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31)

InChI key

XHOLNRLADUSQLD-UHFFFAOYSA-N

Biochem/physiol Actions

Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC50 = 6.3 μM) and little potency against thrombin, trypsin, t-PA, aPC or plasmin inhibition (IC50 >10 μM). Betrixaban exhibits good pharmacokinetic properties and anticoagulant efficacy against various thromboembolism (VTE) events in vivo.
Orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor with anticoagulant efficacy against thromboembolism (VTE) events in vivo.

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This Item
SML3285PHR84151040741
Betrixaban ≥98% (HPLC)

Sigma-Aldrich

SML2845

Betrixaban

Apixaban ≥98% (HPLC)

Sigma-Aldrich

SML3285

Apixaban

Apixaban pkg of 250 mg, certified reference material, pharmaceutical secondary standard

PHR8415

Apixaban

USP

USP

1040741

Apixaban

description

≥98% (HPLC)

description

≥98% (HPLC)

description

pkg of 250 mg, certified reference material, pharmaceutical secondary standard

description

United States Pharmacopeia (USP) Reference Standard

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

-

form

-

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

color

white to beige

color

white to beige

color

-

color

-

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Codes

H302,H373

Precautionary Statements

P301 + P312 + P330 - P314

Hazard Classifications

Acute Tox. 4 Oral - STOT RE 2

Target Organs

Blood

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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