SML0919

ML221

≥98% (HPLC)

• Synonym(s): 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
• Empirical Formula (Hill Notation): C₁₇H₁₁N₃O₆S
• CAS Number: 877636-42-5
• Molecular Weight: 385.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: S(Cc2[o]cc([c](c2)=O)OC(=O)c3ccc(cc3)[N+](=O)[O-])c1ncccn1
• InChI: 1S/C17H11N3O6S/c21-14-8-13(10-27-17-18-6-1-7-19-17)25-9-15(14)26-16(22)11-2-4-12(5-3-11)20(23)24/h1-9H,10H2
• InChI key: UASIRTUMPRQVFY-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ML221 is an antagonist of the apelin receptor (also known as APJ).

ML221 is an antagonist of the apelin receptor (also known as APJ). ML221 blocks Apelin-13 mediated receptor activation (recruitment of β-arrestin) with an IC₅₀ of 1.75 μM.

ML221 is capable of suppressing the cultured-endothelial cell proliferation. In oxygen-induced retinopathy (OIR) mice model, ML221 can block the pathological angiogenesis and increase the recovery of normal vessels into the ischemic regions in the retina. It can also inhibit the formation of neovascular tufts.

Features and Benefits

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Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable