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SML0769

Cu-ATSM

≥98% (HPLC), peroxynitrite inhibitor, powder

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Synonym(s):

CuII(ATSM), Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II), [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

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Size/SKUAvailabilityPrice
5 mg
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€ 119,00
€ 101,15
25 mg
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€ 465,00

About This Item

Empirical Formula (Hill Notation):
C8H14CuN6S2
CAS Number:
Molecular Weight:
321.91
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

€ 101,15

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Product Name

Cu-ATSM, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

, brown to dark red-brown

solubility

DMSO: 0.5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.
Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1).

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This Item
SML3488SML1414SAB2500976
description

≥98% (HPLC)

description

≥98% (HPLC)

description

>98% (HPLC)

description

affinity isolated antibody, buffered aqueous solution

form

powder

form

powder

form

powder

form

buffered aqueous solution

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 0.5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

-

color

, brown to dark red-brown

color

, Faint brown to dark red

color

white to light brown

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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