SML0565

MK-0343

≥98% (HPLC)

• Synonym(s): 7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine, MRK-409
• Empirical Formula (Hill Notation): C₁₉H₁₇F₂N₇O
• CAS Number: 233275-76-8
• Molecular Weight: 397.38
• MDL number: MFCD22683821
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825556
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cn1ncnc1COc2nn3c(nnc3cc2C4CCC4)-c5c(F)cccc5F
• InChI: 1S/C19H17F2N7O/c1-27-16(22-10-23-27)9-29-19-12(11-4-2-5-11)8-15-24-25-18(28(15)26-19)17-13(20)6-3-7-14(17)21/h3,6-8,10-11H,2,4-5,9H2,1H3
• InChI key: GOIFCXRIFSYPFG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

MK-0343 (MRK-409) is a partial agonist for GABAA receptors with comparable Ki values for α1, α2, α3 and α5 containing receptors (0.2 – 0.4 nM). The compound has the greatest agonist activity against α3 receptors, and is brain penatrant, and displays anxiolytic activity in rodent and primate models.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable