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SML0233

Ro 61-8048

≥98% (HPLC)

Synonym(s):

3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide, Ro-61-8048

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Size/SKUAvailabilityPrice
5 mg
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€ 125,00
25 mg
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€ 487,00

About This Item

Empirical Formula (Hill Notation):
C17H15N3O6S2
CAS Number:
Molecular Weight:
421.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

€ 125,00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

faintly yellow to yellow

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(cc1OC)S(=O)(=O)Nc2nc(cs2)-c3cccc(c3)[N+]([O-])=O

InChI

1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)

InChI key

NDPBMCKQJOZAQX-UHFFFAOYSA-N

Application

Ro 61-8048 has been used as a kynurenine 3-monooxygenase (KMO) inhibitor to study its effects on nicotinamide adenine dinucleotide (NAD+) concentration in hepatocytes of mice.

Biochem/physiol Actions

Ro 61-8048 is a potent kynurenine 3-monooxygenase (KMO) inhibitor
Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.
Inhibition of kynurenine 3-hydroxylase by Ro 61-8048 reduces the episodes of dystonia and dyskinesias induced by decreased levels of kynurenic acid.

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This Item
SAE0004HPA031115HPA056942
description

≥98% (HPLC)

description

-

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

form

powder

form

solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: ≥15 mg/mL

solubility

-

solubility

-

solubility

-

color

faintly yellow to yellow

color

-

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3



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