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SAB4503993

Sigma-Aldrich

Anti-phospho-Survivin (pThr34) antibody produced in rabbit

affinity isolated antibody

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100 μG
€393.00

€393.00

Ships within 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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100 μG
€393.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

€393.00

Ships within 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 16 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI accession no.

O15392

UniProt accession no.

O15392

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr34)

Gene Information

human ... BIRC5(332)

General description

Survivin is also termed as BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5). It is a multifunctional protein. It belongs to the inhibitor of apoptosis protein (IAP) family. BIRC5 is expressed in fetal tissues and several human malignancies like melanoma. Survivin is located on human chromosome 17q25.

Immunogen

The antiserum was produced against synthesized peptide derived from human Survivin around the phosphorylation site of Thr34.

Immunogen Range: 11-60

Biochem/physiol Actions

Survivin/BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5) plays a major role in ATL (adult T-cell leukemia/lymphoma) cell viability. It can block apoptosis and induce the multiplication of cell. BIRC5 also plays a major role in the development of cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
110578

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Functional polymorphism -31C/G in the promoter of BIRC5 gene and risk of nasopharyngeal carcinoma among chinese.
Ma F, et al.
PLoS ONE, 6(2), e16748-e16748 (2011)
Correlation of local and systemic expression of survivin with histopathological parameters of cutaneous melanoma.
Jovic M, et al.
Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review, 73(11), 1022-1029 (2016)
Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability.
Pise-Masison CA, et al.
Blood, 113(17), 4016-4026 (2009)
Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy.
Bieche I, et al.
Molecular Cancer, 10(1), 23-23 (2011)

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