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Key Documents

SAB4502725

Sigma-Aldrich

Anti-CHP2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Calcineurin B homologous protein 2, Hepatocellular carcinoma-associated antigen 520

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 22 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

O43745

UniProt accession no.

O43745

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHP2(63928)

General description

Anti-CHP2 antibody detects endogenous levels of total CHP2 protein.
The CHP2 (calcineurin like EF-hand protein 2) gene is mapped to human chromosome 16p12.2. It encodes a 23kDa protein containing myristoylation site at its N-terminal and four EF-hand Ca2+ binding motifs. The gene is predominantly expressed in small intestine and cancer cells.

Immunogen

The antiserum was produced against synthesized peptide derived from human CHP2.

Immunogen Range: 101-150

Biochem/physiol Actions

The protein encoded by CHP2 (calcineurin like EF-hand protein 2) gene serves as an important cofactor of Na+/H+ exchanger isoform 1 and maintains high intracellular pH in cancer cells. CHP2 protects cells from dying due to serum deprivation. Overexpression of the gene is observed in ovarian cancer and it is involved in the growth, proliferation, invasion and metastasis of cancer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.
Ammar YB
The Embo Journal, 25(11), 2315-2325 (2006)
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
Jin Q
In Vivo, 21(4), 593-598 (2007)
Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Li QH
Genes Cells, 16(4), 416-426 (2011)
Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.
Ben Ammar Y
Acta Crystallographica Section F, Structural Biology and Crystallization Communications, 61(Pt 10), 956-958 (2005)

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