Anti-VIP36/LMAN2 is produced in rabbit using as immunogen a synthetic peptide of human LMAN2 conjugated to KLH. VIP36 (vesicular-integral protein of 36 kDa) is a member of the leguminous-type (L-type) lectin family, which also includes ERGIC-53, ERGL and VIPL. L-type lectins are type I transmembrane proteins composed of a large luminal domain comprising a carbohydrate recognition domain (CRD) and a short cytosolic domain that mediates sorting within the early secretory pathway. VIP36 localizes mainly to the Golgi apparatus and cycles between the Golgi and the ER.
Application
Anti-VIP36/ LMAN2 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Vesicular-integral protein of 36 kDa (VIP36) binds high mannose type glycoproteins in a Ca2+-dependent manner and may facilitate their sorting, trafficking and quality control.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Role of the Lectin VIP36 in Post-ER Quality Control of Human alpha1-Antitrypsin
Reiterer V, et al.
Traffic, 11(8), 1044-1055 (2010)
Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36
Satoh T, et al.
Test, 282(38), 28246-28255 (2007)
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