C-X3-C motif chemokine receptor 1(CX3CR1) is a seven transmembrane domain G‐protein‐coupled receptor. The gene is located on human chromosome 3p22.2. CX3CR1 is expressed in different types of inflammatory cells.
Immunogen
CX3CR1 antibody was raised against a peptide corresponding to amino acids 2 to 21 of human CX3CR1. The sequence differs from those of mouse and rat CX3CR1 by four amino acids (3,4).
Application
Anti-CX3CR1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
C-X3-C motif chemokine receptor 1 (CX3CR1) functions as a receptor for fractalkine. It is implicated in the progression of inflammatory and vascular disorders.
Features and Benefits
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500204.
Physical form
Supplied in PBS with 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Journal of neuroinflammation, 16(1), 120-120 (2019-06-09)
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Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures.
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