RAB1708
Human SMPD1 ELISA
for serum, plasma and cell culture supernatants
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
technique(s)
ELISA: suitable
assay range
inter-assay cv: <12%
intra-assay cv: <10%
shipped in
wet ice
storage temp.
−20°C
General description
Sphingomyelin phosphodiesterase-1 (SMPD1) gene encodes for acid sphingomyelinase (aSMase), which is involved in the hydrolysis of sphingomyelin to ceramides and phosphorylcholine in the late endosomes and lysosomes. Ceramides act as proinflammatory and proapoptotic second messengers. Mutations in the SMPD1 gene are associated with a lack of aSMase, leading to Niemann-Pick disease type A and B. The SMPD1 gene is mapped to the human chromosome at 11p15.1–11p15.4.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol
Ching Y L, et al.
Human Genetics, 552?562-552?562 (2003)
Analysis of the sphingomyelin phosphodiesterase 1 gene (SMPD1) in Turkish Niemann?Pick disease patients: Mutation profile and description of a novel mutation
Ayukt A, et al.
Gene, 484-486 (2013)
Sphingomyelin phosphodiesterase 1 (SMPD1) mediates the attenuation of myocardial infarction-induced cardiac fibrosis by astaxanthin
Yu S, et al.
Biochemical and Biophysical Research Communications, 503(2), 637-643 (2018)
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