P3136

Polydeoxyguanylic acid · Polydeoxycytidylic acid sodium salt

double-stranded homopolymer

• Synonym(s): Poly(dG) • Poly(dC)
• CAS Number: 119039-74-6
• UNSPSC Code: 41106305
• NACRES: NA.51
• MDL number: MFCD00131969

Properties

• form: solid
• storage temp.: −20°C

Description

Application

Polydeoxyguanylic acid • Polydeoxycytidylic acid (Poly(dG) • Poly(dC)) is a high molecular weight double-stranded homopolymer DNA model compound used for conformational studies of DNA structure dynamics and drug and small molecule interactions.

Preparation Note

Polymers composed of dG and dC can be difficult to dissolve. The recommended dissolution method for poly(dG) • poly(dC) is to suspend the polymer in a minimum of 15 μl per unit in water or buffer and heat to 50-55 °C for 30 minutes with occasional mixing by inversion.

Other Notes

High molecular weight double-stranded homopolymer

One unit will yield an A₂₆₀ of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)