M5192

Anti-Matrix Metalloproteinase-26, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-MMP-26
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD04974757
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 6

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): western blot: 1:1,000
• UniProt accession no.: Q9NRE1
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MMP26(56547)

Description

General description

Matrix metalloproteinase-26 (MMP-26) is also known as matrilysin-2 and endometase. It is expressed in normal tissues and also in human carcinoma cells. MMP-26 possesses a propeptide domain, a signal peptide and a catalytic domain but does not have the hemopexin-like domain which is common to other members of its family. The MMP-26 gene is localized to human chromosome 11p15.3.

Immunogen

synthetic peptide corresponding to the propeptide domain of human matrix metalloproteinase-26.

Biochem/physiol Actions

By immunoblotting against the reduced protein, the antibody identifies a band at 30 kDa (zymogen).

Matrix metalloproteinase-26 (MMP-26) degrades fibronectin, type IV collagen and activated pro-metalloproteinase-9. MMP-26 also aids in development of tumors.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids