M2946

Mosapride citrate salt dihydrate

≥98% (HPLC), solid, 5-HT₄ receptor agonist

• Synonym(s): 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl ]-2-morpholinyl]methyl]benzamide citrate dihydrate
• Empirical Formula (Hill Notation): C₂₁H₂₅ClFN₃O₃ · C₆H₈O₇ · 2H₂O
• CAS Number: 636582-62-2
• Molecular Weight: 650.05
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817957
• NACRES: NA.77
• MDL number: MFCD00874415
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Product Name: Mosapride citrate salt dihydrate,
• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• solubility: DMSO: ≥5 mg/mL
• originator: Takeda
• storage temp.: 2-8°C
• SMILES string: O.O.OC(=O)CC(O)(CC(O)=O)C(O)=O.CCOc1cc(N)c(Cl)cc1C(=O)NCC2CN(CCO2)Cc3ccc(F)cc3
• InChI: 1S/C21H25ClFN3O3.C6H8O7.2H2O/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14;7-3(8)1-6(13,5(11)12)2-4(9)10;;/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);2*1H2
• InChI key: KVKIQHMTGSGTFO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

5-HT₄ receptor agonist and 5-HT₃ receptor antagonist

Mosapride is found effective against chronic gastritis, functional dyspepsia and gastro-oesophageal reflux disease. It is useful in treating many other symptoms associated with gastrointestinal disorders. Mosapride is known to improve digestive motility.

Features and Benefits

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves