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Key Documents

M1695

Sigma-Aldrich

MAZ51

≥98% (HPLC), solid

Synonym(s):

3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one

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About This Item

Empirical Formula (Hill Notation):
C21H18N2O
CAS Number:
Molecular Weight:
314.38
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

≥98% (HPLC)

form

solid

color

orange

solubility

DMSO: 11 mg/mL

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)c4ccccc14

Biochem/physiol Actions

Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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