I4907
Anti-IKKε/IKK-i, C-Terminal antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IKB Kinase
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~80 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
western blot: 0.5-1 μg/mL
UniProt accession no.
application(s)
research pathology
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... IKBKE(9641)
General description
IKK-epsilon/IKK-I belongs to IκB kinase complex and express mainly in immune cells. IKK-I express in response to proinflammatory cytokines such as tumor necrosis factor-α, IL-, IL-6 and stimulate NF-κB activation, hence referred as inducible IκB kinase . Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoblotting to detect human IKK epsilon/IKK-I. Anti-IKK epsilon/IKK-I antibodies can react specifically with human IKK epsilon/IKK-I and show no cross reactivity with IKK α, IKK β and IKK γ.
Specificity
The antibody show no cross-reactivity to IKKα, IKKβ, or IKKγ.
Immunogen
Synthetic peptide corresponding to amino acids 701-716 of human IKK-epsilon/IKK-I conjugated to KLH.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoprecipitation and western blot.
Features and Benefits
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Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Jian-Ping Guo et al.
The Journal of biological chemistry, 285(6), 3676-3684 (2009-11-27)
IKKepsilon has recently been identified as a breast cancer oncogene. Elevated levels of IKKepsilon are associated with cell survival and growth. Here, we show that IKKepsilon interacts with and phosphorylates estrogen receptor alpha (ERalpha) on serine 167 in vitro and
Suhu Liu et al.
Blood advances, 2(23), 3428-3442 (2018-12-07)
To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compared
Israel Cañadas et al.
Nature medicine, 24(8), 1143-1150 (2018-07-25)
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that
T Shimada et al.
International immunology, 11(8), 1357-1362 (1999-07-28)
Using the suppression subtractive hybridization technique, we isolated a novel kinase, IKK-i, whose message is drastically induced by lipopolysaccharide (LPS) in the mouse macrophage cell line RAW264. 7. The predicted protein contains the kinase domain in its N-terminus, which shares
Serkan Ismail Göktuna
EXCLI journal, 21, 436-453 (2022-04-09)
IKBKE have been associated with numerous cancers. As a result, IKBKE have emerged as potential target for cancer therapy. Accumulating evidence support that IKBKE orchestrate tumor cell survival in cancers. Here we evaluated the possible link between IKBKE and ERK
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