F3422

Flt-3/Flk-2 ligand human

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)

• Synonym(s): FL
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD01093789

Properties

• biological source: human
• Quality Segment: 100
• recombinant: expressed in E. coli
• assay: ≥98% (SDS-PAGE and HPLC)
• form: lyophilized powder
• potency: ≤1.0 ng/mL
• mol wt: 17.6 kDa
• packaging: pkg of 5 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P36888
• storage temp.: −20°C
• Gene Information: human ... FLT3(2322)

Description

General description

Mouse and human Flt-3 ligand share ~72% homology and both demonstrate cross-species activity.

Biochem/physiol Actions

Flt-3/Flk-2 Ligand (FL, or Flt-3L) is a transmembrane glycoprotein that binds and activates the Flt-3 receptor. Expression of Flt-3 is primarily restricted among hematopoietic cells to the most primitive progenitor cells.

Physical form

Lyophilized, 0.2 μm sterile filtered, with with 0.5x PBS.

Analysis Note

The biological activity is measured by its ability to stimulate the proliferation of human AML5 cells.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)