F0430

Fenobam

≥98% (HPLC), solid

• Synonym(s): N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea
• Empirical Formula (Hill Notation): C₁₁H₁₁ClN₄O₂
• CAS Number: 57653-26-6
• Molecular Weight: 266.68
• NACRES: NA.77
• PubChem Substance ID: 24894721
• UNSPSC Code: 12352200
• MDL number: MFCD00868019
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >20 mg/mL
• originator: Johnson & Johnson
• storage temp.: 2-8°C
• SMILES string: CN1CC(=O)N=C1NC(=O)Nc2cccc(Cl)c2
• InChI: 1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
• InChI key: DWPQODZAOSWNHB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR₅ constitutive activity in vitro (IC₅₀ = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu₅ receptor with K_d values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.

Potent, selective, noncompetitive metabotropic glutamate receptor antagonist (mGluR5). Displays anxiolytic activity.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges