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Key Documents

E9645

Sigma-Aldrich

Estrone sulfamate

≥98%

Synonym(s):

1,3,5(10)-Estratrien-17-one 3-sulfamate

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0.2 MG
€182.00

€182.00


Estimated to ship on25 April 2025



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0.2 MG
€182.00

About This Item

Empirical Formula (Hill Notation):
C18H23NO4S
CAS Number:
Molecular Weight:
349.44
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

€182.00


Estimated to ship on25 April 2025


biological source

synthetic (organic)

Quality Level

Assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

[S](=O)(=O)(N)Oc1cc2c(cc1)[C@@H]3[C@H]([C@H]4[C@](CC3)(C(=O)CC4)C)CC2

InChI

1S/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1

InChI key

RVKFQAJIXCZXQY-CBZIJGRNSA-N

Application

Lead compound for design of steroid sulfatase inhibitors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates.
L W Woo et al.
Journal of medicinal chemistry, 39(7), 1349-1351 (1996-03-29)
A Purohit et al.
Biochemistry, 34(36), 11508-11514 (1995-09-12)
Steroid sulfatases are responsible for the hydrolysis of 3beta-hydroxy steroid sulfates, such as cholesterol and pregnenolone sulfate, and have an important role in regulating the synthesis of estrogenic steroids, from estrone sulfate and dehydroepiandrosterone sulfate, in endocrine-dependent tumors. Although little

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