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About This Item
Empirical Formula (Hill Notation):
C15H12I2O4
CAS Number:
Molecular Weight:
510.06
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
storage temp.
2-8°C
SMILES string
OC(=O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1
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Biochem/physiol Actions
DITPA, an analog of L-thyroxine, has inotropic but not chronotropic effects on heart muscle. It also stimulates myocardial angiogenesis after infarction by interaction with integrin αvཪ3 at the cell surface.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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M A Hassan Talukder et al.
American journal of physiology. Heart and circulatory physiology, 300(2), H702-H711 (2010-12-07)
There is emerging evidence that treatment with thyroid hormone (TH) can improve postischemic cardiac function. 3,5-Diiodothyropropionic acid (DITPA), a TH analog, has been proposed to be a safer therapeutic agent than TH because of its negligible effects on cardiac metabolism
Charles F Verge et al.
The Journal of clinical endocrinology and metabolism, 97(12), 4515-4523 (2012-09-21)
Monocarboxylate transporter 8 (MCT8) is a thyroid hormone-specific cell membrane transporter. MCT8 deficiency causes severe psychomotor retardation and abnormal thyroid tests. The great majority of affected children cannot walk or talk, and all have elevated serum T(3) levels, causing peripheral
James A Kuzman et al.
Canadian journal of physiology and pharmacology, 85(3-4), 311-318 (2007-07-07)
Diiodothyropropionic acid (DITPA) is a thyroid hormone analog that is currently in phase II clinical trials. However, there have not been any studies to comprehensively analyze its effect on myocyte morphology. In addition, long-term studies with DITPA have not been
Eugene Morkin et al.
Journal of molecular and cellular cardiology, 37(6), 1137-1146 (2004-12-02)
Thyroid hormone has the unique properties of lowering cholesterol in hypothyroid individuals and improving cardiac performance. Beginning in the 1950s, extensive efforts were made to develop thyroid hormone analogs that could utilize the cholesterol-lowering property in euthyroid individuals without affecting
Niranjan Maitra et al.
Journal of cardiovascular pharmacology, 50(5), 526-534 (2007-11-22)
We have used an oligonucleotide microarray to identify genes that are affected by congestive heart failure and those influenced by treatment with DITPA and DITPA in combination with captopril using a rat postinfarction model. The most striking result when comparing
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