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D4268

NG,NG-Dimethylarginine dihydrochloride

≥98% (TLC), powder, NOS inhibitor

Synonym(s):

asym-Dimethylarginine, ADMA

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10 mg
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€ 72,40
50 mg
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€ 254,00

About This Item

Empirical Formula (Hill Notation):
C8H18N4O2 · 2HCl
CAS Number:
220805-22-1
Molecular Weight:
275.18
UNSPSC Code:
12352209
PubChem Substance ID:
24278027
NACRES:
NA.77
MDL number:
MFCD00270857
Assay:
≥98% (TLC)
Form:
powder

€ 72,40

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Product Name

NG,NG-Dimethylarginine dihydrochloride,

assay

≥98% (TLC)

Quality Segment

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI key

SYLNVYJOPZWPJI-ILKKLZGPSA-N

Gene Information

General description

NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Application

NG,NG- Dimethylarginine dihydrochloride has been used:
  • to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
  • as a standard for measuring L-arginine and dimethylarginines
  • to study its effects on hepatic deterioration

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

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This Item
D0390311204SMB00938
NG,NG-Dimethylarginine dihydrochloride

Sigma-Aldrich

D4268

NG,NG-Dimethylarginine dihydrochloride

NG,NG′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt ≥99% (TLC)

Sigma-Aldrich

D0390

NG,NG′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt

NG,NG′-Dimethyl-L-arginine, Dihydrochloride Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.

Sigma-Aldrich

311204

NG,NG′-Dimethyl-L-arginine, Dihydrochloride

Dimethyl-L-arginine ≥95% (HPLC)

Sigma-Aldrich

SMB00938

Dimethyl-L-arginine

description

-

description

≥99% (TLC)

description

Cell permeable. Endogenous inhibitor of nitric oxide synthesis in vitro and in vivo. Does not exhibit any significant inhibitory effect on NOS activity.

description

≥95% (HPLC)

form

powder

form

powder

form

solid

form

powder

assay

≥98% (TLC)

assay

≥99% (TLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

solubility

water: 50 mg/mL, clear, colorless

solubility

methanol: 10 mg/mL

solubility

water: 50 mg/mL

solubility

-

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Gene Information

-

Gene Information

-

Gene Information

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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