D0567

DIF-3

≥99% (HPLC), solid

• Synonym(s): 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3
• Empirical Formula (Hill Notation): C₁₃H₁₇ClO₄
• CAS Number: 113411-17-9
• Molecular Weight: 272.72
• NACRES: NA.77
• PubChem Substance ID: 24724455
• UNSPSC Code: 12352200
• MDL number: MFCD05865230
• Assay: ≥99% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥99% (HPLC)
• form: solid
• solubility: DMSO: soluble 46 mg/mL
• SMILES string: CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O
• InChI: 1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3
• InChI key: JWBMZIJMSBFBIY-UHFFFAOYSA-N

Description

General description

Differentiation-inducing factor-3 (DIF-3) is a monochlorinated metabolite of differentiation-inducing factor-1 (DIF-1), that belongs to the differentiation-inducing factor (DIF) family.[1]

Application

DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia[2], as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention[3], as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes

Biochem/physiol Actions

DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.

Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.[1]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)