C5732

CA-074

synthetic (organic), ≥98% (HPLC), cathepsin B inhibitor, powder

• Synonym(s): (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline
• Empirical Formula (Hill Notation): C₁₈H₂₉N₃O₆
• CAS Number: 134448-10-5
• Molecular Weight: 383.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892580
• NACRES: NA.77
• MDL number: MFCD00797531
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: CA-074, ≥98% (HPLC)
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• solubility: methanol: 1 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10?,11-,12-,13-,14-/m0/s1
• InChI key: ZEZGJKSEBRELAS-NSIINPIOSA-N

Description

Application

CA-074 has been used as a cathepsin B inhibitor:

• to study its effect on pseudotyped viruses bearing S proteins harboring R642M and N714K using HeLa cells[1]
• to determine the role of autophagy in glucose deprivation (GD)-induced damage[2]
• to study its effects on neuronal function upon exposure to His-cathepsin B (CATB)[2]

Biochem/physiol Actions

CA-074 is a potent and a selective inhibitor of cathepsin B. It is useful to study the biological function of cathepsin B in vivo. Studies show that CA-074 can also inhibit cathepsin L under reducing conditions.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)