C0993

CGP 57380

≥98% (HPLC)

• Synonym(s): CGP57380, N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine
• Empirical Formula (Hill Notation): C₁₁H₉FN₆
• CAS Number: 522629-08-9
• Molecular Weight: 244.23
• NACRES: NA.77
• PubChem Substance ID: 24724432
• UNSPSC Code: 12352200
• MDL number: MFCD03861062
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear, H₂O: <2 mg/mL
• storage temp.: 2-8°C
• SMILES string: Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
• InChI: 1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
• InChI key: UQPMANVRZYYQMD-UHFFFAOYSA-N

Description

Application

CGP 57380 has been used:

• as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells[1]
• as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation[2]
• as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells[3]

Biochem/physiol Actions

CGP 57380 is a β-catenin nuclear translocation inhibitor,[3] which prevents the proliferation of several cancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).[4]

CGP 57380 is a cell-permeable selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type N95 (US)